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Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children.

Identifieur interne : 000035 ( Main/Exploration ); précédent : 000034; suivant : 000036

Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children.

Auteurs : Neil R. Brett [Canada] ; Paula Lavery [Canada] ; Sherry Agellon [Canada] ; Catherine A. Vanstone [Canada] ; Susan Goruk [Canada] ; Catherine J. Field [Canada] ; Hope A. Weiler [Canada]

Source :

RBID : pubmed:29861487

Descripteurs français

English descriptors

Abstract

In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (n = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (n = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: n = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.

DOI: 10.3390/nu10060680
PubMed: 29861487


Affiliations:

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Le document en format XML

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<term>Child</term>
<term>Child Nutritional Physiological Phenomena</term>
<term>Child, Preschool</term>
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<term>Immune System (physiopathology)</term>
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<term>Urban Health</term>
<term>Vitamin D (administration & dosage)</term>
<term>Vitamin D (therapeutic use)</term>
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<term>Vitamin D Deficiency (immunology)</term>
<term>Vitamin D Deficiency (physiopathology)</term>
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<term>Carence en vitamine D (immunologie)</term>
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<term>Carence en vitamine D (sang)</term>
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<term>Enfant d'âge préscolaire</term>
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<term>Vitamine D (usage thérapeutique)</term>
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<term>Études de suivi</term>
<term>Études transversales</term>
<term>Évaluation de l'état nutritionnel</term>
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<div type="abstract" xml:lang="en">In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (
<i>n</i>
= 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (
<i>n</i>
= 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male:
<i>n</i>
= 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (
<i>p</i>
< 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.</div>
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<AbstractText>In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8⁻5.9 years (
<i>n</i>
= 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8⁻8.7 years old (
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<i>n</i>
= 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (
<i>p</i>
< 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to.</AbstractText>
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